ABSTRACT
BACKGROUND: Esophageal cancer is commonly treated with surgery, concurrent chemoradiotherapy (CCRT), or a combination of both. The correlation between the hematological parameters during CCRT and early survival of esophageal cancer has not been fully evaluated. MATERIALS AND METHODS: We analyzed the records of 65 esophageal cancer patients treated by CCRT between 2007 and 2010 retrospectively. The association between CCRT‑associated myelosuppression, demographic variables, and survival rates were analyzed by univariate and multivariate analysis. RESULTS: The univariate analysis showed that tumor extent of T3-4, a higher stage of tumor, a lower albumin level, grade 3 or higher anemia and thrombocytopenia, and interruptions in treatment affected survival rates. Further, the multivariate analysis revealed that stage IV (P = 0.030) is an independently negative prognostic factor for a one‑year survival rate. Stage IV (P = 0.035), tumor extent of T3-4 (P = 0.002), and grade 3-4 thrombocytopenia (P = 0.015) are independently negative prognostic factors for a two‑year survival rate. CONCLUSIONS: Severe decrease in platelet count during CCRT independently affects survival of esophageal cancer patients in addition to stage of the tumor.
ABSTRACT
Toxoplasma gondii antibody titers as determined by either the indirect hemagglutination test or the methylene blue dye test were determined for a group of aborigines and for Chinese as well as for swine, cats, rats, dogs and one bovine, all resident on the island of Taiwan. None of the 194 aborigines and only 3 (1.97%) of the 152 Chinese were found to be positive. Of 433 swine tested 132 (30.5%) were positive. Thirteen (27.7%) of 47 domestic pet cats were positive while none of 11 feral cats were positive. None of the 29 rats, 3 dogs or the one bovine were positive. Possible reasons for the lack of infection in Chinese is discussed.